Aseptic cartridge filling for autoinjectors

This critical operation requires high precision in three aspects: fill volume; air gap; and physical stopper placement. Achieve extremely accurate stopper placement and bubble-free filling thanks to servo-driven mechanical placement with precise vacuum control.

Filling of nested cartridges in the SA25 Aseptic Filling Workcell

Risk reduction

A standardized robotic solution creates a cycle of reduced risk compared to conventional systems. Automation results in less human error, which leads to less contamination of the drug product. This is the main regulatory focus for aseptic processing. Workcells from Cytiva support manufacturer compliance with Annex 1 and FDA guidelines for aseptic processing.

Cleanroom operator holds a tray of nested vials that have been filled and closed by the SA25 Aseptic Filling Workcell.

Nested ready-to-use cartridges

Reduce risk even further with ready-to-use (RTU) cartridges with nested plungers. Nested cartridges eliminate glass-to-glass contact resulting in fewer particles and cosmetic issues that cause rejects.

Discover how our 1^st to market gloveless, robotic innovative approach supports EU-ANNEX-1 and other regulatory compliance. Learn how we’ve created a standard solution for aseptic filling that delivers higher control, reduced risk of contamination and less human error, lower cost, and faster time to market.

Resources

Hands off the goods

It’s time to adopt closed, automated aseptic filling processes for the drugs of today and tomorrow.

Close-up shot of vials moving through the SA25 Aseptic Filling Workcell

Closed robotic workcells

Learn how they differ from conventional systems and how your drug product operations can benefit.

SA25 Aseptic Filling Workcell - no glove ports

Customer story: WuXi Biologics

This CDMO reached its first GMP batch release 15 months after purchasing a workcell from Cytiva.

Filled, nested syringes inside the SA25 Aseptic Filling Workcell

Syringe fill-finish

Pre-filled syringes have many advantages, but what are the requirements for today’s complex biologics?