The Vanrx Microcell is a fully integrated gloveless robotic isolator for pharmaceutical vial filling that can be used to make clinical trial supplies and develop new products. These include autologous cell therapies and personalized medicines.
The Microcell can help bring drug products to market faster by providing cost-effective, flexible filling capacity.
This new vial filling machine replaces manual filling and small-volume filling machines that combine with biosafety cabinets, RABS or isolators. These options can be expensive, and difficult and time-consuming to integrate.
Build clinical and development filling capacity at a lower cost and in less time.
Fill up to four products in a single day. Can fill 2R-50R nested vials with toolless changeover and decontamination in 15 minutes.
Gloveless isolator eliminates operator error and buffers operators from drug products.
The Microcell is easy to learn and simple to operate.
Can fit in a small space with little supporting infrastructure.
Specification |
|
Throughput |
Up to 300 units per load / 1,200 units possible in 8-hour shift |
Fill volume |
0.1 – 50 mL (2R – 50R) |
Pump type |
Peristaltic |
Pump accuracy |
±0.5% (±1.0% below 1 mL) |
In-process (IPC) weigh |
Programmable up to 100% of vials |
Product contact materials |
fill path assembly only (single-use) |
Container / closure |
2R-50R pre-sterilized nested vials and press-fit closures with industry standard 13/20mm stoppers. |
Materials |
Full 316L stainless steel interior and robotics |
Interior classification |
Grade A |
Exterior classification |
Grade C or D (depending on regulations) |
Control system |
21 CFR Part 11 compliant |
Dimensions |
1.70m wide x 1.5m long x 2.2m high (5.6′ x 4.9′ x 7.2′) |
Required floor space |
13m2 (140 sq./ ft.) |
Electrical |
208-240V VAC |
Compressed air |
6 Bar clean, dry air |
Dec 10 - Dec 12, 2018
Huntington Beach, CA, USA
401
Mar 11 - Mar 13, 2019
San Diego, CA, USA
215
Mar 11 - Mar 14, 2019
Santa Clara, CA, USA
TBD
September 7, 2018 - Blog, cell therapy, Featured, Gene therapy
Manual aseptic processing is definitely not the best approach— it’s the last resort. Vanrx would go a step further and suggest that manual aseptic processing should end. The technologies and process understanding exist to do away with operator-driven aseptic technique.
Read MoreAugust 13, 2018 - Article, Featured, Innovation
Vanrx Pharmasystems’ Microcell Vial Filler was hand-picked by industry magazine Pharmaceutical Manufacturing for a 2018 Pharma Innovation Award. This is the second award presented in 2018 to the Microcell Vial filler, following its Interphex ‘Best in show’ award in April.
Read MoreThe Vanrx Microcell Vial Filler changes the economics of aseptic filling for clinical trials and product development. Multiple development candidates can come to market faster by bringing these activities in-house, and at a lower cost than outsourcing.
Learn MoreThe Microcell Vial Filler can reduce your critical vein-to-vein time by allowing GMP manufacturing of personalized therapies.
Fast start-up and decontamination times allow Microcells to be ready when needed, and to change over quickly to the next patient’s therapy. Single-use consumables, including filling needles and product bags eliminate cross-contamination. Robotic filling eliminates operator error from manual processes. A standard machine design allows scale to be added as products succeed in trials and are commercially approved.
Learn MoreWhen your products succeed in early trials and need to move to higher volume late-stage trials or commercial manufacturing, the process is easily scaled to the Vanrx SA25 Aseptic Filling Workcell.
The SA25 is capable of filling the same vials and closures used in the Workcell, or can also process syringes and cartridges if the dosage format changes for your commercial launch. The same gloveless robotic approach is used across the full line of Vanrx Aseptic Workcells.
Learn more