The Microcell Vial Filler is a closed gloveless robotic isolator for filling vials. It is best suited for personalized medicines, clinical trial supplies and drug development (e.g. stability, toxicology, formulation).
The Microcell is a standard machine that can be installed and validated quickly (≤ 6 months). The closed isolator and removal of human intervention provides an optimal aseptic process, resulting in safer drug products for patients.
Customers are using the Microcell for the following applications:
Microcell Customers
Users of the Microcell Vial Filler include Roche / Genentech and Adaptive Phage Therapeutics.
The delivery lead time for the Microcell is 3 months, and customers have reached GMP production within 6 months following their purchase order. Compare this against manual filling or semi-automated filling in biosafety cabinets or glovebox isolators that may take a year or more to integrate, using significantly more labour.
The Microcell can fill up to four different drug products in an 8-hour shift. Single-use consumables and a fast 15-minute decontamination cycle shorten time to fill and changeover times.
The Microcell is a fully integrated gloveless robotic isolator that removes the need for operator intervention through an optimized aseptic process. The Microcell is equipped with the Vanrx Dynamic Peristaltic Pump, which provides 10x less variability vs. conventional peristaltic pumps in low fill volume applications.
The Microcell occupies the same area as a biosafety cabinet and is a standalone machine with simple utility requirements. The Microcell POD, offered in cooperation with a G-CON remanufactured clean room POD, is the first turnkey aseptic filling facility and is available pre-installed and qualified for shipping worldwide.
Throughput |
Maximum of 300 units per load with 1,200 units producible in an 8-hour shift |
Pump type |
Vanrx Dynamic Peristaltic Pump |
Fill volume range |
0.1-50 mL |
Pump accuracy |
10x less variability than conventional pumps |
In-process control (IPC) fill volume check |
Programmable, up to 100% of units |
Machine vision |
Robotic guidance, container absence / presence |
Product contact materials |
Fill path assembly only (single-use) |
Interior classification |
Grade A |
Exterior classification |
Grade C or D (depending on regulator) |
Dimensions |
2.28 x 1.97 x 2.20m (7’5″ x 6’5″ x 7’2″) |
Required cleanroom space |
13 m2 (140 sq. ft.) |
Electrical |
240 VAC, <60 A, single phase |
Compressed air |
6 Bar clean dry air, <10 CFM |
Control system |
21 CFR Part 11 compliant |
Options |
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Drug product bag load cell |
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Automated clean-in-place (CIP) |
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Completely closed gloveless isolator that eliminates operator interventions.
Drug product contact is limited to single-use flow path and inside of container.
Vanrx Dynamic Peristaltic Pump provides the best available accuracy and precision.
Uses press-fit closures with integrated stoppers, eliminating the particle risk and quality problems of crimp capping and stopper bowls.
Single-use flow paths prevent cross-contamination.
March 18, 2020 - Featured
Vanrx is introducing the Dynamic Peristaltic Pump, a new pump technology that helps biopharmaceutical companies bring advanced therapies to patients.
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Learn about how Vanrx’s customers are using the Microcell
Vanrx's partners in the Matrix Alliance provide nested vials and closures for use on the Microcell