The Microcell Vial Filler is a closed gloveless robotic isolator for filling vials. It is best suited for personalized medicines, clinical trial supplies and drug development (e.g. stability, toxicology, formulation).
The Microcell is a standard machine that can be installed and validated quickly (≤ 6 months). The closed isolator and removal of human intervention provides an optimal aseptic process, resulting in safer drug products for patients.
Customers are using the Microcell for the following applications:
Microcell Customers
Users of the Microcell Vial Filler include Roche / Genentech and Adaptive Phage Therapeutics.
The delivery lead time for the Microcell is 3 months, and customers have reached GMP production within 6 months following their purchase order. Compare this against manual filling or semi-automated filling in biosafety cabinets or glovebox isolators that may take a year or more to integrate, using significantly more labour.
The Microcell can fill up to four different drug products in an 8-hour shift. Single-use consumables and a fast 15-minute decontamination cycle shorten time to fill and changeover times.
The Microcell is a fully integrated gloveless robotic isolator that removes the need for operator intervention through an optimized aseptic process.
The Microcell occupies the same area as a biosafety cabinet and is a standalone machine with simple utility requirements. The Microcell POD, offered in cooperation with a G-CON remanufactured clean room POD, is the first turnkey aseptic filling facility and is available pre-installed and qualified for shipping worldwide.
Throughput |
Maximum of 300 units per load with 1,200 units producible in an 8-hour shift |
Pump type |
Peristaltic Pump |
Fill volume range |
0.5-50 mL |
Fill accuracy |
±0.5 (±1.0% below 1 mL) |
In-process control (IPC) fill volume check |
Programmable, up to 100% of units |
Product contact materials |
Fill path assembly only (single-use) |
Interior classification |
Grade A |
Exterior classification |
Grade C or D (depending on regulator) |
Dimensions |
2.28 x 1.97 x 2.20m (7’5″ x 6’5″ x 7’2″) |
Required cleanroom space |
13 m2 (140 sq. ft.) |
Electrical |
240 VAC, <60 A, single phase |
Compressed air |
6 Bar clean dry air, <10 CFM |
Control system |
21 CFR Part 11 compliant |
Options |
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Drug product bag load cell |
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Automated clean-in-place (CIP) |
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Completely closed gloveless isolator that eliminates operator interventions.
Drug product contact is limited to single-use flow path and inside of container.
Uses press-fit closures with integrated stoppers, eliminating the particle risk and quality problems of crimp capping and stopper bowls.
Single-use flow paths prevent cross-contamination.
Learn about how Vanrx’s customers are using the Microcell
Vanrx's partners in the Matrix Alliance provide nested vials and closures for use on the Microcell