Precise Syringe Filling Machines

Pre-filled syringes make it easier for clinicians to administer life-saving drugs. Vanrx's SA25 Aseptic Filling Workcell is highly accurate and precise in filling and stoppering syringes, including PFS units installed into auto-injectors. The SA25 will produce batches up to 25,000 units.



Think bubble-free filling. Vanrx’s SA25 Aseptic Filling Workcell delivers extremely accurate stopper placement and bubble-free filling. This is achieved through servo-driven mechanical placement with precise vacuum control and inert gas backfill.



All filling and closing processes are performed robotically using a recipe-driven control system. This makes production predictable, even when filling and stoppering complex drug products. 



Vanrx’s syringe filling machines can be built and installed within 12 months of your purchase order, with validation taking 3 months or less. This means you can reach revenue faster. The SA25’s compact design and use of ready-to-use syringes and stoppers provides a 65% reduction in facility footprint versus conventional systems.

Benefits of the SA25 Aseptic Filling Workcell

Flexible syringe filling machine
  • Cost-effective

    Reduces operating costs vs. competing small-batch fillers by up to 50%. Only one operator required.

  • Flexible filling

    The SA25 can fill nested pre-sterilized syringes, vials and cartridges, with fast changeover times between formats of less than one hour.

  • Standard

    A standard design provides a scalable model that can expand production quickly, as needed.

  • Reduced risk

    No human intervention necessary during syringe filling and stoppering. No glass-to-glass contact. Automated viable and non-viable environmental monitoring.

  • Nested syringes and stoppers

    Nested syringes and stoppers simplify your process, and reduce both capital and operating expenses.

Operator at Singota Solutions using the SA25 Aseptic Filling Workcell for filling vials, syringes and cartridges.



Fully automated, gloveless cGMP filling


Robotic handling of nested syringes and stoppers


Batch size range of 1,000-25,000 units

Syringe sizes

All standard syringe sizes, including in 100 and 160-unit configurations


Single-use fill path and product contact materials


Full 316L stainless steel interior and robotics


Vapor-phase hydrogen peroxide, Clean-in-Place (CIP)

Environmental Monitoring

Automated viable and non-viable environmental monitoring

Control System

21 CFR Part 11 compliant


1.5m wide x 4.2m long x 2.4m high (4.9′ x 13.8′ x 7.9′)

Particle levels

The interior of the gloveless isolator maintains ISO 5 or better particle levels. Machine can be installed in an ISO 8 or Grade C / D room (depending on regulatory area).

SCHOTT KAISHA and Vanrx Pharmasystems announce product compatibility for primary packaging of sterile injectables

March 13, 2018 - Matrix Alliance, News

SCHOTT KAISHA and Vanrx Pharmasystems are announcing compatibility between SCHOTT KAISHA’s ready-to-use nested syringes, cartridges and stoppers, and Vanrx’s Aseptic Filling Workcells. The two companies have worked together to confirm these containers and closures as Product Sets as part of the Matrix Alliance.

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Blog: Syringe Fill-Finish Manufacturing Requirements for Today's Complex Biologics

This article focuses on syringe fill-finish challenges that pharmaceutical companies are experiencing with complex biologics, including drug stability, plunger placement techniques, and syringe and plunger formats. It explains the need for a highly accurate, precise, and repeatable syringe filling process.

Read more

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