Vial Filling Precision

Vanrx makes two gloveless robotic isolator systems for vial filling: the Microcell Vial Filler and the SA25 Aseptic Filling Workcell. Together, these function as a scalable vial filling system from drug development through commercialization.

Gloveless isolators


The design of Vanrx vial filling machines removes the need for human intervention in the filling process. Therefore, the isolator can be completely closed and gloveless. A gloveless isolator reduces risk to the drug product, and robotics provide a highly repeatable filling and closing process.

Flexible aseptic filling


Both the Microcell and SA25 can fill nested, pre-sterilized ISO vials from 2R to 50R. Changeover and decontamination between products can occur in as little as 15 minutes. For late stage clinical and commercial quantities, the SA25 can also fill nested syringes and cartridges.



Vial filling is performed by a peristaltic pump and single-use or multi-use filling assemblies. These ensure sterility and reduce downtime between batches. Vanrx Workcells use peristaltic pumps, and are accurate within ±0.5% between 1-100 mL and ±1.0% under 1 mL.

Vanrx Microcell Vial Filler

The Vanrx Microcell is designed for drug development (formulation, stability, toxicology, etc.) and early phase clinical trial production. It is also well-suited for the production of personalized medicines, such as cell & gene therapies, immuno-oncology and mRNA products.

See details about the Microcell

SA25 Aseptic Filling Workcell

The SA25 Aseptic Filling Workcell is designed for late phase clinical trial production and commercial drug products. The SA25 can flexibly produce vials, syringes and cartridges, making it well-suited for producing smaller volume, targeted therapies filled into multiple delivery formats.

See details about the SA25

Benefits Of Vanrx Vial Filling Machines

  • Cost-effective

    Require less space versus competing filling machines, and can be installed in ISO 8 / Grade C/D space (depending on regulator). Only require one operator.

  • Flexible filling

    Vanrx Workcells can fill a full range of 2R-50R nested vials. Many vial sizes require little or no change parts.

  • Standard

    All Vanrx vial filling machines are standard designs. This means they can be built quickly, which provides a highly scalable production model. Produce clinical supplies on the Microcell and scale to the SA25 for commercialization.

  • Reduced risk

    No human intervention necessary during vial filling / capping. No glass-to-glass contact. Automated viable and non-viable environmental monitoring.

  • Nested containers

    Nested vials and press-fit closures provide security for your products. No glass-to-glass contact and no aluminum particles.

Vanrx is announcing a Product Set use in its vial filling machines, involving ready-to-use pharmaceutical vials made by Ompi with press fit closures made by Daikyo Seiko.

Blog: Pharmaceutical industry transitioning to press-fit vial closures

If press-fit closures were the current standard for sealing pharmaceutical vials, would pharmaceutical companies switch to aluminum crimp caps? Driven by data, pharma companies would not make the switch. This blog reviews the benefits of plastic closures in replacing aluminum crimp caps.

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